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During the reign of Sixtus IV, a team of Renaissance painters that included Sandro Botticelli, Pietro Perugino,Pinturicchio, Domenico Ghirlandaio and Cosimo Roselli, created a series of frescos depicting the Life of Moses and the Life of Christ, offset by papal portraits above and trompe l’oeil drapery below. These paintings were completed in 1482, and on 15 August 1483 Sixtus IV celebrated the first mass in the Sistine Chapel for the Feast of the Assumption, at which ceremony the chapel was consecrated and dedicated to the Virgin Mary.

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